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KMID : 0363219960340060968
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Korean Journal of Dermatology
1996 Volume.34 No. 6 p.968 ~ p.972
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The Genetics of Vitiligo in Korean Patients
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Abstract
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Background :
@EN Vitiligo is a common disorder whose cause is not well understood. Up to 30% of patients had another family member with vitiligo which means that vitiligo is a heritable condition. We could not find any study fof the genetics of vitiligo in
Korean
literature.
@ES Objective :
@EN The purpose of this study was to clarify how genetic factors are involved in the pathogenesis of vitiligo Korean patients
@ES Methods :
@EN We analyzed the 65 Korean vitiligo probands and their Each family was ascertained through a proband afflicted with vitiligo.
@ES Results :
@EN 1. Focal type of vitiligo(44.6%) appeared to be with the highest frequency followed by the non-segmental generalized type (35.4%) and segmental type(20.0%).
2. The of vitiligo not related with sex (p>0.9, X2 =0.14).
3. There was a clear pattern of a familial aggregation of the vitiligo disease. In 29(44.6%) of dence of people affected among their 789 relagtives (first, second and third-degree) was also found to be 9.13±1.03%.
4. Several families in this study were shown to have father-son transmission of vitiligo, which indicates that vitiligo does not fit an x-linked inheritance.
5. There is a statistically significant departure from the expected which is inconsistent with a utosomal dominant inheritance (p<0.001, x2 =52.32).
6. A single recessive model at the autosomal locus is not an explanation in determining the cause of vitiligo. The threshold trait among first-degree relatives(8.8%) shows a tendency to approach the square root of the frequency in the general
population(10%) compared to those of dominant(50%) or recessive(25%) models. This result is consistent with a model of multifactorial inheritence for vitiligo.
@ES Conclusion :
@EN these result indicate that vitiligo is determined by a polygenic nature.
(Kor J Dermatol 1996;34(6) : 968~972)
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